Retatrutide (also known by its developmental code LY3437943) is a first-in-class triple agonist peptide. Its composition is specifically engineered to target three different metabolic receptors: GLP-1, GIP, and Glucagon (GCGR).
Chemical Composition & Structure
Retatrutide is a synthetic peptide consisting of 39 amino acids. Its backbone is based on the GIP (glucose-dependent insulinotropic polypeptide) sequence but is heavily modified for stability and multi-receptor potency.